Calcitriol has what effect on PTH production?

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Multiple Choice

Calcitriol has what effect on PTH production?

Explanation:
Calcitriol suppresses PTH production. It binds the vitamin D receptor on parathyroid cells, directly downregulating PTH gene transcription and decreasing PTH synthesis. At the same time, calcitriol increases intestinal absorption of calcium, raising serum calcium levels; the higher calcium further inhibits PTH secretion via the calcium-sensing receptors on the parathyroid gland. Clinically, this negative feedback helps keep PTH in check when calcitriol is adequate. So, the correct effect is reduction of PTH production, not stimulation, no effect, or resistance.

Calcitriol suppresses PTH production. It binds the vitamin D receptor on parathyroid cells, directly downregulating PTH gene transcription and decreasing PTH synthesis. At the same time, calcitriol increases intestinal absorption of calcium, raising serum calcium levels; the higher calcium further inhibits PTH secretion via the calcium-sensing receptors on the parathyroid gland. Clinically, this negative feedback helps keep PTH in check when calcitriol is adequate. So, the correct effect is reduction of PTH production, not stimulation, no effect, or resistance.

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